Combined Oral Ivermectin and 5% Permethrin Cream to Treat Severe Scabies Published May 6, 2026 N Engl J Med 2026;394:1814-1823 DOI: 10.1056/NEJMoa2411721 Abstract Background Severe scabies, a rare parasitic skin disease characterized by abundant skin mites, may be life-threatening and poses public health concerns worldwide. A combination of standard-dose oral ivermectin and topical scabicides is r...