Subretinal Gene Therapy for X-Linked Retinoschisis Published June 10, 2026 N Engl J Med 2026;394:2223-2234 DOI: 10.1056/NEJMoa2515953 Abstract Background X-linked retinoschisis is a recessive disease characterized by progressive macular degeneration and vision loss due to pathogenic variation in RS1. Methods We administered a single subretinal injection of an AAV8 vector containing human RS1 compl...