Abstract Insulin resistance (IR), a primary precursor to type 2 diabetes, is characterized by impaired insulin action in tissues1. However, diagnostic methods remain expensive and inaccessible, which hinders early intervention2,3. Here we present the WEAR-ME study, a large, remotely conducted study of IR (n = 1,165 participants; median body mass index (BMI) = 28 kg m−2, median age = 45 years, medi...